Dr. Pezzulo is physician scientists who recently acquired an NIH K01 to determine how HSP90 induces the hypersecretion of mucus and metaplasia of goblet cells in CF lung disease. He hypothesizes that inhibition of HSP90 induces transdifferentiation of goblet cells to ciliated cells by blocking ERBB2/EGFR signaling, and he is testing this possibility using lineage tracing. This pathway may also be important in the production of excessive and altered mucus by the CF intestine.