Dr. Uc’s research focuses on CF and non-CF exocrine pancreatic disease, CFRD, and rAAV-mediated gene therapy to the pancreas, using CF pig and ferret models. Her clinical research includes the study of acute and chronic pancreatitis in children, and she directs a U01 consortium on pediatric chronic pancreatitis. This U01 provides considerable translational strengths pertaining to modifier genes that affect CF pancreatic disease. In this context, Dr. Uc has generated a knockout ferret (SPINK1 gene) that models inherited chronic pancreatitis, in collaboration with the Center’s Animal Model Core, and her group is using this model to understand overlapping CFTR-independent mechanisms of pancreatitis-associated diabetes. She collaborates heavily with Drs. Engelhardt and Norris on dissecting the pathogenesis of CFRD within R01- and R24-funded programs.