Dr. Engelhardt’s research includes: 1) study of the molecular and cellular pathogenesis of CF lung disease and CF-related diabetes, 2) development of transgenic ferret animal models in which to study stem cell biology in the context of CF, including ferrets designed for lineage tracing of islet progenitors in the CF pancreas, and 3) development of gene therapies for CF lung and pancreatic disease. His laboratory is adept at the construction and use of many types of recombinant viral vectors (including adenovirus, AAV, lentivirus, retrovirus, and bocavirus). He also is PD/PI of a team science R24 that focuses on the pathogenesis of CF-related diabetes in CF ferrets and includes a clinical trial in CF infants and children <6 yrs of age. This grant has been converted into an NIDDK RC2 (application under review).