Dr. Rahmouni’s research focuses on molecular and cellular regulation of altered glucose metabolism in diabetes. In collaboration with Drs. Norris and Engelhardt, he is studying how the central nervous system controls the secretion of pancreatic polypeptide (PP/PPY) by pancreatic islets and the implications of this effect for glucose metabolism in CFRD. His group is using CF and PPY-KO ferret models to study these processes, and hypothesize that altered innervation of the remodeled CF pancreas is responsible for reduced PP secretion in CF humans and ferrets.