Dr. Sinn's research focuses on developing integrating vector systems for the treatment of CF lung disease. His R01-funded research focuses on the development of a piggyBac hybrid vector system that integrates into airway epithelial cells, and the engineering of transposases and zinc-fingers to integrate transgenes into safe-harbor genomic loci. These systems, in addition to novel lentiviral pseudotypes developed by Dr. Sinn, are being used for lung-directed gene therapy in the CF pig and ferret models.