Dr. Yan's research pertains to the molecular biology of rAAV and human Bocaviruses (HBoV), and to their development as recombinant viral vectors for use in gene therapy of CF. Most recently, he generated new recombinant HBoV serotypes with an intestinal tropism. Through his CF Foundation-funded research, he is generating a novel genetic ferret model with targeted integration of a CFTR mini-exon. This model will make it possible to test gene-editing strategies in vivo. Dr. Yan also collaborates with Drs. Engelhardt, McCray, and Sinn in testing vectors in the CF ferret models.