Current Grants:

Yang, Ling, Ph.D. Role of Long Noncoding RNA-encoded Micropeptide in CFRD Beta Cell Dysfunction

Ryan, Amy, Ph.D.  Targeting the exocrine pancreas to restore function in Cystic Fibrosis-Related Diabetes

Polgreen, Philip, M.D.  Determining the risk for pancreatic, endocrine, and kidney related disorders attributable to the CFTR heterozygote state

Limoli, Dominique, Ph.D. Identification of E. coli genes necessary for colonization of the gastrointestinal tract in cystic fibrosis ferrets

Past Grants: 

Sun, Xingshen, Ph.D. Generation of a conditional CFTR Knockout Ferret

Pezzulo, Alejandro, M.D. Cellular tropism and effects of an evolved viral vector for airway epithelia gene therapy

Rosen, Bradley, D.O.  Mucin subtype regulation of epithelial inflammation in mucoobstructive lung disease

Voynow, Judith, M.D.  The Alarmin and RAGE axis: A Novel Therapeutic Target for CF

Larson-Ode, Katie, M.D.  Glucose Profile in the Home Setting in Young Children with Cystic Fibrosis

Li, Xiaopeng, Ph.D.  Role of disrupted ASL pH regulation in small airways in CF lung disease pathogenesis

Keiser, Nicholas, Ph.D. Inflammation in the Neonatal CFTR-knockout Ferret Lung

Norris, Andrew, M.D., Ph.D. The Role of CFTR in Hepatic Insulin Action

Uc, Aliye, M.D. Delivery of AAV9 Vector to Wild-Type and Cystic Fibrosis Pig Pancreas and Lungs

Stewart, Zoe, M.D., Ph.D.rAAV-Mediated Pancreatic Gene Therapy in a Cystic Fibrosis Ferret Model

Xing, Yi, Ph.D. Deep Survey of the Cystic Fibrosis Transcriptome by mRNA Sequencing

Wine, Jeffrey, Ph.D. Mucus Secretion by CFTR Deficient Ferret Submucosal Glands

Maury, Wendy, Ph.D. Development of Highly Transducing Glycoproteins for Transgene Delivery Into Airway Epithelial Cells

Fiegel, Jennifer, Ph.D. Development of LOS-Modified Nanoparticles for Improved Airway Epithelial Uptake

Parekh, Kalpaj, M.D. Epithelial Stem Cells in a Lung Transplant Model

Liu, Xiaoming, Ph.D. High-Level Ectopic Expression of CFTR Imposes a Selective Disadvantage to Airway Epithelial Stem/Progenitor Cells

Giangrande, Paloma, Ph.D. RNA Aptamers for Cytoplasmic Delivery of Nucleic Acids

Raikwar, Sudhanshu, Ph.D. Deviation of Insulin-Producing Cells from ES Cells

Banfi, Botond, Ph.D. Long Term Gene Expression by Epidermal Stem Cells

Keshavjee, Shaff, M.D. Repair of Damaged Lungs for Transplantation Using and ex-vivo Gene Therapeutic Strategy

Cornell, Robert, Ph.D. Generation of a Transgenic Zebrafish for Optimization of Gene Correction Methodologies

Snyder, Jeanne, Ph.D. Enhancement of Innate Immunity in Cystic Fibrosis via SP-D Complementation

McCaffrey, Anton, Ph.D. Zinc Finger Nucleases Targeting Hepatitis B Virus DNAs

Henry, Michael, Ph.D. Cellular Uptake and in vivo Pharmacodynamics of Cholesterol-siRNAs

Harper, Scott, Ph.D. Autoregulated AAV Vectors for Inducible RNA Interference

Stipp, Christopher, Ph.D. Enhancing the Neurite Outgrowth Potential of Neuronal Precursor Cells

Sinn, Patrick, Ph.D. Targeted Integration of a Lentiviral Vector

Jones, Bradley, Ph.D. Gene Therapy for Phenylketonuria using an Adherent Bacterial Vector

Singh, Pradeep, M.D. CFTR-Mediatred Gene Correction of Biofilm Formation in the CF Airway

Yan, Ziying, Ph.D. Hybrid rAAV Genomes for Gene Therapy of Cystic Fibrosis

Wu, Chun-Fang, Ph.D. Harmful Effects of Integrating AAV Vectors

Weeks, Daniel, Ph.D. Site Directed Mutagenesis Using Triplex Target Sites

Vermeer, Paola, Ph.D. Goblet Cell Hyperplasia and Gene Transfer in CF

Stapleton, Jack, M.D. A GBV-C Gene Therapy Vector for Cystic Fibrosis

Roller, Richard, Ph.D. Cell-Specific Targeting of Herpes Simplex Virus in Gene Therapy for Cystic Fibrosis

Rice, Kevin, Ph.D. Reversibly PEGylated Gene Delivery Particles for Treating Cystic Fibrosis

Mallampalli, Rama, M.D. The CCT Promoter to Drive High-Level Expression of CFTR

Liang, Luchuan, Ph.D. A Study of Epidermal Stem Cells in the Airway

Engelhardt, John F., Ph.D. Differentiation Capacity of Transformed Airway Cell Lines in Human Bronchial Xenografts: Animal Models Core Developmental Project

Kang, Yubin, Ph.D. Hematopoietic Stem Cell Gene Transfer for Hemophilia A

Green, Steven H., Ph.D. Gene Transfer into Spiral Ganglion Neurons in vivo

Wang, Guoshun, D.V.M, Ph.D.Binding and fusion of ampho-envelope to airway cells

Stein, Colleen S., Ph.D. Transgene Tolerance: a Role for Apoptosis

Stecenko, Arlene, M.D. Delivery of CFTR Protein Using membrane Translocating Sequences

Sanders, David A, Ph.D. Direct Gene Transfer to Intact Airway Epithelia for CF

Ostedgaard, Lynda S., Ph.D. Optimization of the CFTR Coding Sequence for Efficient Packaging into the AAV Vector

Messerle, Louis, Ph.D. AAV-Associated Cluster Contrast Agents for MR/CT Imaging of Vector Biodistribution

Look, Dwight C., M.D. Adenoviral Mechanisms for Inhibition of Interferon Signal Transduction

Lamb, Fred, S., M.D., Ph.D. Site-Directed Mutation of ES Cells by Oligonucleotides

Klingelhutz, Aloysius J., Ph.D. Reversibly Immortal Human Airway Epithelium

Dagle, John M., Ph.D. Modified Antisense Oligonucleotides as Pseudomonas Antimicrobials

Lotery, Andrew, M.D. Development of Gene Therapy for Batten Disease

Dunnwald, Martine, Ph.D. Epidermal Stem Cells as a Gene Delivery System

Zabner, Joseph, M.D. Study of Chimera Recombinant Adenovirus

Wiemer, David, Ph.D. & Welsh, Michael, M.D., Co-PI, Modification of the Cell Surface to Aid Gene Transfer

McLennan, Geoffrey, Ph.D. Evaluating Gene Therapy Using a Fluorescent Marker

McCray, Paul, M.D. Optimization of Retroviral Vectors for Mucosal Delivery

Krieg, Arthur, M.D. Development of Non-Immune Activating Gene Therapy Vectors for Cystic Fibrosis

Kline, Joel, M.D. Role of CPG Motifs in Plasmid DNA as a Barrier to Gene Transfer

Engelhardt, John F., Ph.D. Circular Intermediates of rAAV as Novel Gene Transfer Vectors

Duan, Dongsheng, Ph.D. Analysis of rAAV Integration Specificity

Davidson, Beverly, Ph.D. Retroviral Gene Transfer to Airway Epithelia with MMLV-based Vectors

Cheng, Pi-Wan, Ph.D. Ciliated Cell-Specific Gene Transfer

Johnson, Alan, Ph.D. Targeted Modulation of Vasopressin in Brain Magnocellular Neurons by Adenovirus-Mediated Gene Therapy

Bickenbach, Jackie, Ph.D. Long Term Gene Expression by Epidermal Stem Cells